Table 1 Baseline characteristics
|
SBP < 130 and LVH N = 33 |
SBP ≥130 and LVH N = 66 |
SBP < 130 and no LVH N = 68 |
SBP ≥130 and no LVH N = 76 | P value | |
|---|---|---|---|---|---|
| Age, years, mean ± SD | 76 ± 7.2 | 77.4 ± 8.9 | 72.8 ± 8.2 | 72.9 ± 8.2 | 0.002 |
| Caucasian, % | 31 (93.9) | 65 (98.5) | 67 (98.5) | 71 (93.4) | 0.38 |
| Men, % | 15 (45.4) | 33 (50) | 30 (44.1) | 36 (47.4) | 0.92 |
| Obesity, % | 23 (69.7) | 31 (47) | 38 (55.8) | 38 (50) | 0.15 |
| Cancer, % | 7 (21.2) | 24 (36.4) | 13 (19.2) | 14 (18.4) | 0.05 |
| Ejection fraction, mean ± SD* | 61 ± 7.2 | 60 ± 7.7 | 58 ± 7.8 | 61 ± 8.8 | 0.35 |
| CAD, % | 12 (36.3) | 22 (33.3) | 21 (30.9) | 11 (14.5) | 0.02 |
| CVA, % | 1 [3] | 7 (10.6) | 4 (5.9) | 5 (6.6) | 0.51 |
| DM, % | 18 (54.5) | 32 (48.5) | 32 (47) | 38 (50) | 0.91 |
| HTN, % | 29 (87.9) | 62 (93.9) | 64 (94.1) | 71 (93.4) | 0.71 |
| A fib, % | 8 (24.2) | 11 (16.7) | 9 (13.2) | 10 (13.1) | 0.49 |
| Hyperlipidemia, % | 24 (72.7) | 41 (62.1) | 55 (80.9) | 56 (73.7) | 0.11 |
| Pulmonary disease, % | 10 (30.3) | 16 (24.2) | 13 (19.1) | 22 (28.9) | 0.49 |
| Chronic liver disease, % | 1 [3] | 4 [6] | 5 (7.3) | 2 (2.6) | 0.52 |
| ACEIs, % | 17 (51.5) | 32 (48.5) | 29 (42.6) | 39 (51.3) | 0.73 |
| ARBs, % | 4 (12.1) | 16 (24.2) | 9 (13.2) | 15 (19.7) | 0.29 |
| Calcium channel blockers, % | 7 (21.2) | 29 (43.9) | 21 (30.9) | 35 (46) | 0.03 |
| Beta blockers, % | 21 (63.6) | 46 (69.7) | 38 (55.9) | 35 (46) | 0.03 |
| Thiazide diuretics, % | 13 (39.4) | 29 (43.9) | 29 (42.6) | 34 (44.7) | 0.96 |
| Loop diuretics, % | 11 (33.3) | 21 (31.8) | 19 (27.9) | 24 (31.6) | 0.93 |
| K sparing diuretics, % | 2 [6] | 1 (1.52) | 9 (13.2) | 3 (3.95) | 0.03 |
| Clonidine, % | 0 (0) | 4 [6] | 1 (1.5) | 3 (3.95) | 0.32 |
| Vasodilators, % | 2 [6] | 17 (25.8) | 7 (10.3) | 5 (6.6) | 0.004 |
| SBP mmHg, mean ± SD | 123.9 ± 4.13 | 140.5 ± 8 | 122 ± 5.3 | 139.3 ± 8.3 | <0.0001 |
| DBP mmHg, mean ± SD | 69.7 ± 5.52 | 73.1 ± 7.32 | 70.9 ± 5.4 | 74.7 ± 6.6 | 0.0002 |
| PTH pg/mL, median [IQR] | 59 [35, 83] | 56 [42, 82] | 67 [36, 92] | 65 [45, 96] | 0.81 |
| Hemoglobin g/dL, mean ± SD | 13 ± 1.44 | 12.4 ± 1.89 | 12.7 ± 1.66 | 13 ± 1.84 | 0.13 |
| Phosphorus mg/dL, mean ± SD | 3.35 ± 0.43 | 4 ± 3.28 | 3.46 ± 0.66 | 3.43 ± 0.64 | 0.31 |
| Bicarbonate mEq/L, mean ± SD | 27.9 ± 2.96 | 27.2 ± 2.94 | 26.4 ± 3.32 | 26.9 ± 3.12 | 0.13 |
| 25-Vitamin D ng/mL, median [IQR] | 31.8 [23, 43] | 36.9 [26, 48.7] | 38.7 [21.3, 48.7] | 28.9 [19.8, 48.8] | 0.54 |
| Albumin g/dL, mean ± SD | 4 ± 0.30 | 4 ± 0.31 | 4 ± 0.36 | 4.1 ± 0.32 | 0.36 |
| Baseline GFR, mean ± SD | 48.2 ± 18.1 | 45 ± 18.8 | 47.6 ± 2.3 | 53.3 ± 2.1 | 0.06 |
| Proteinuria, mg/g, median [IQR] | 100 [7, 214] | 100 [46, 303] | 74.4 [8.4, 104] | 100 [16.7, 333] | 0.01 |